The player(s) have to guide Ren and Stimpy as they retrieve parts to rebuild their newest and latest invention. Most of the game play is of the side view platform type. However, the game can be played both one or two player through the same stages. This game was preceded by Veediots! and followed by Fire Dogs.
Ren comes to see what Stimpy is doing. Stimpy is making his latest invention, The Mutate-o-Matic. It can turn household garbage into food. Stimpy shows Ren how it works by switching the lever to No Way causing the invention to explode into pieces. Now Ren and Stimpy must find the missing pieces for the invention.
In one player the player controls either Ren or Stimpy and the computer controls the other character who will simply follow; however, the player can swap the character they control at almost any time during game play. In two player, players controls one character each, both within the same screen (no split screen). In one or two player several special moves can be performed by both characters standing close and a player pressing certain buttons simultaneously, the move differs depending on which buttons are pressed and whether the player is controlling Ren or Stimpy. The ability of swapping characters during game play in one player means the player can perform all the special moves not just those available for one character. The moves include: Stimpy throwing Ren to cover long distance such as over a hole.
Ren pulling off Stimpy's nose and throwing it to attack enemies (his nose regrows instantly). Ren slapping Stimpy across the face while shouting "You stupid idiot!" having no purpose other than amusement. Powdered Toastman has the ability to rescue the player's character(s) from bottomless pits. However, the rescue costs the player a portion of their health. If the player's health is low enough to die with one more hit, no amount of health is taken away when the Powered Toast Man rescues the player. Other hazards that are traditionally considered enemies can cause damage to the player; like water at the zoo level for example.